Endocrine Abstracts

IntroductionSubacute thyroiditis is a rare cause of thyrotoxicosis arising in the context or following viral infections. This disorder is more frequent in women than in men (male/female ratio of 1:4). In addition to respiratory symptoms, the SARS-CoV-2 infection (COVID-19) has been associated with extrapulmonary manifestations. Herein we report a male patient with hyperthyroid symptoms starting four-week after a positive test for COVID-19.<p class="a...

Introduction: Environmental pollutants especially those endowed with endocrine disrupting activities have been shown to contribute to metabolic related diseases suggesting that hormonal deficit conditions as observed in post-menopausal women may constitute aggravating conditions. To explore this hypothesis, we used the model developed in the laboratory which consists in a chronically exposure of mice to low-dosed chemicals in mixture incorporated in a high-fat-high-sucrose die...

Introduction: Although in-vitro models suggest GH-induced differentiation, migration and survival of astrocytes and oligodendrocytes, no studies had been published in-vivo. We want to evaluate the efficacy and safety of GH associated with physical therapy compared to placebo in patients with complete spine injury (SI) and associated GH deficiency (GHD).Methods: Eighteen Patients with complete SI were screened for GHD (glucagon test). 12 severe (...

Introduction: Hormonal replacement therapy (HRT) increases bone mineral density (BMD). Controversy exists regarding residual effect after withdrawal. We aimed to explore the effect of HRT and HRT withdrawal on: i) BMD and bone microarchitecture assessed by trabecular bone score (TBS); ii) fat (FMI), lean (LMI) and appendicular lean (ALMI) mass indexes.Methods: The OsteoLaus Cohort assessed 1500 women (50–80 years) for BMD, TBS, total energy expendit...

Nur77 is an orphan nuclear receptor included in the NR4A family. This protein has been studied as a transcriptional regulator of glucose metabolism in different tissues. We aimed to investigate the endogenous role of Nur77 on energy and metabolic homeostasis. For this purpose, we used male and female Nur77-deficient mice and their wild-type littermates. We challenged them to standard diet and high fat diet, and analyzed different parameters involved in energy balance (food int...

Introduction: Obesity and its associated chronic comorbidities represent a worldwide health problem in epidemic increase. Recent researches have reported notable differences in the amino acids metabolism signatures between obese, mild insulin resistant but non-diabetic, and lean individuals. Moreover, amino acids metabolites are emerging as strong predictors in the development of diabetes in obesity. The contribution of the obese adipose tissue from various depots to the syste...

The pocket protein family members, pRb, p107 and p130, are negative regulators of the cell cycle. But, while the role of pRB as a tumor suppressor has been extensively established, genetic inactivation of p107 or p130 is uncommon in tumors. Previous studies have shown that p130 cooperates with the CDK inhibitor p27Kip1 restricting proliferation of mouse intermediate lobe pituitary cells. Accordingly double knockout mice show higher incidence of pituitary tumors than single KO ...

RET is a tyrosine-kinase receptor having a GPI-linked co-receptor or GFRα. Moreover, RET has four different ligands (GDNF, NTN, ART and PSP) with its respective co-receptor (GFRα-1,-2,-3 and 4). Pituitary cells are differentiated specialized secretory cells. Sommatotrophs are responsible for growth during infancy and puberty until achievement of the final adult height. Although genetic factors leading to somatotroph hypoplasia are well known, no much is known about t...

Background: We previously showed that menopausal hormone therapy (MHT) favorably affects both bone density and microarchitecture with persistent benefit after its withdrawal (1). Looking for indirect factors contributing to bone effects, we investigated the relation between MHT and changes on fat and lean (muscular) tissue. Existing results on MHT and body composition are conflicting and large cohort studies are lacking.Material and methods: The OsteoLau...

Introduction: The parathyroid gland is made up of principal cells and oxyphilic cells, surrounded by stroma, whose main component is adipose tissue, which accounts for 25% of the content of the parathyroid in adults. In parathyroid adenomas, prominent parathyroid cellularity can be observed, with a very marked decrease in the stroma. Parathyroid lipoadenoma is a rare variant of parathyroid adenoma, characterized by hyperfunctioning parathyroid cells in an abundant fatty stroma...